Journal article
Traffic-related air pollution exposure over a 5-year period is associated with increased risk of asthma and poor lung function in middle age
G Bowatte, B Erbas, CJ Lodge, LD Knibbs, LC Gurrin, GB Marks, PS Thomas, DP Johns, GG Giles, J Hui, M Dennekamp, JL Perret, MJ Abramson, EH Walters, MC Matheson, SC Dharmage
European Respiratory Journal | EUROPEAN RESPIRATORY SOC JOURNALS LTD | Published : 2017
Abstract
Current evidence concerning the impact of exposure to traffic-related air pollution (TRAP) on adult respiratory morbidity mainly comes from cross-sectional studies. We sought to establish more robust measures of this association and potential gene-environment interactions using longitudinal data from an established cohort study. Associations between measures of TRAP (nitrogen dioxide (NO2) and distance to major roads) and wheeze, asthma prevalence and lung function were investigated in participants of the Tasmanian Longitudinal Health Study at 45- and 50-year follow-ups. Generalised estimating equations were used to quantify associations and the potential modifying effect of glutathione S-tr..
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Funding Acknowledgements
The authors thank all the Tasmania Longitudinal Health Study participants, staff and funding bodies. We are grateful to Adrian Lowe (University of Melbourne and Murdoch Childrens Research Institute, Melbourne, Australia) for his valuable discussions and feedback. G. Bowatte, L.D. Knibbs and J.L. Perret are supported by the Centre for Air Quality and Health Research and Evaluation (CAR), a National Health and Medical Research Council-funded centre for research excellence.